Wild Senna

Wild Senna (Cassia hebecarpa)
Cassia hebecarpa is an herbaceous perennial legume that can grow as tall as 6 feet. It grows in the eastern part of North America, from Ontario to Georgia. It is mostly found in areas with moist soils, but it can also occasionally be found in drier locations. Senna varieties are found all over the world, but many of their medicinal properties are similar. Several Senna species are widely used as laxatives, both historically and in modern medicine, due to the presence of compounds called anthraquinones (Belt, 2002). The laxative effect is derived from the leaves or fruit pods of the plant. In traditional medicines, Senna is used as a tea, an extract, or syrup. Modern uses provide the extract in pill form. (Cirillo & Capasso, 2015)
Historical Use
Historical information on the use of senna can be found in Nicholas Culpeper’s English Physician; and Complete Herbal written in 1789. The leaves of Senna (usually the Senna alexandrina/Cassia senna variety) were used as a laxative and emetic. It was also thought to cleanse the body and blood by purging “obstructions,” melancholy, and phlegm. Jacob Bigelow’s American Medical Botany highlights Cassia marilandica, a close cousin of Cassia hebecarpa. Although demonstrating similar medicinal virtues to that of Senna alexandrina, Cassia marilandica required a third more to have the same effect. Thus, Senna alexandrina was preferred and imported to America.

Latest Research
- Sennosides vs magnesium hydroxide vs polyethylene glycol as a treatment for constipation in anorectal malformation: a randomized crossover trialby Butsarin Nate-Anong on August 26, 2025 at 10:00 am
CONCLUSION: While PEG showed a trend towards better fecal clearance and Sennosides was preferred by users, no statistically significant differences in efficacy or user preference were found among the three laxatives.
- Comparison of Various Diet Regimens Involving Sennoside for Bowel Cleansing Prior to Colonoscopy: A Randomized Controlled Trialby Hilmi Bozkurt on May 30, 2025 at 10:00 am
CONCLUSION: Patients using cost-effective Senna for bowel cleansing before colonoscopy can safely consume low-fiber foods on the day before the procedure. In the present study, a clear diet offered no benefit over a more comfortable and better-tolerated diet in terms of colon cleanliness.
- Fourier transformed near-infrared combined with chemometric analysis: Sustainable quantification of natural laxatives in Cassia plantsby Haroon Elrasheid Tahir on March 5, 2025 at 11:00 am
FT-NIR and chemometrics are vital analytical tools for medicinal plant quality control. This study aimed to establish a rapid technique for quantifying sennoside A and B in Cassia plants (i.e., leaves, pods, and flowers) using Fourier Transformed Near-infrared Spectroscopy (FT-NIR). The calibration models were established by partial least squares (PLS), GA-PLS (Genetic Algorithm PLS), Bi-PLS (Backward Interval PLS), and Si-PLS (Synergy Interval PLS). Sennosides contents in Cassia were quantified…
- Efficacy of 1 L Polyethylene Glycol Plus Ascorbic Acid With Linaclotide Versus Senna for Bowel Preparation: A Multicenter, Endoscopist-Blinded, Randomized Controlled Trial (Apple Trial)by Natsumi Maeda on February 25, 2025 at 11:00 am
INTRODUCTION: No bowel preparation (BP) for colonoscopy achieves optimal efficacy and tolerability. Combining polyethylene glycol plus ascorbic acid (PEG-Asc) with adjuvants has been explored to enhance cleansing efficacy and reduce the required volume. The aim of this study was to evaluate whether adding 0.5 mg linaclotide to 1 L PEG-Asc (1 L-PEG/AL) improves superior cleansing compared with adding 24 mg senna (1 L-PEG/AS), which we previously reported to be noninferior to the standard regimen…
- Useful Bowel Preparation with Ultralow-Volume (500 mL) Polyethylene Glycol for Colonoscopy: A Retrospective Studyby Yusuke Mizuno on February 3, 2025 at 11:00 am
CONCLUSIONS: Our established ultralow-volume (500 mL) PEG is safe and useful as a bowel preparation method.
References
Belt, S. (2002). Wild Senna Plant Guide. Retrieved from https://plants.usda.gov/factsheet/pdf/fs_sehe3.pdf
Cirillo, C., & Capasso, R. (2015). Constipation and Botanical Medicines: An Overview. Phytother Res, 29(10), 1488-1493. doi:10.1002/ptr.5410
Other Resources
Natural Medicines record: Senna (Access to UI only)