Feverfew (Tanacetum parthenium)
Feverfew is a perennial plant with leaves that are similar to those of chrysanthemum and daisy-like flowers. It is native to the Balkans and Asia Minor, though it has been introduced widely throughout Europe and North America. As the name suggests, Feverfew has long been used as a traditional medicine to reduce fevers and has been used in a variety of other treatments.
In Parkinson’s text (1640), Feverfew is noted as being useful to treat a great many ailments. He advises to use it to treat menstrual issues and and to assist in expulsion of placenta during the birthing process. Feverfew is also noted to be useful in treating coughs and chest congestion as well as to help expel bladder stones. Parkinson also states that the plant is “effectuall for all paines of the head” and was also used to treat vertigo. Feverfew was even recommended to be used to remove freckles and as a remedy for overdose of opium. While many of these uses would seem laughable now, there is an increasing body of research investigating the use of Feverfew to treat headaches and migraines.
A number of biologically active chemicals have been isolated from Feverfew essential oils, including camphor, camphene, juniper camphor, bornyl acetate, bornyl isovalerate, and borneol (Mohsenzadeh, Chehregani, & Amiri, 2011). In addition, sesquiterpene lactones, including parthenolide, are produced in the leaves and have been the target of an increasing amount of study (Rabito et al., 2014). Many studies have been conducted regarding the use of Feverfew extracts to treat or prevent migraines, and clinical studies have provided promising but mixed results (Wider, Pittler, & Ernst, 2015). However, the sesquiterpene lactones have seen recent promising evidence in studies examining their use as an anti-parasitic agent, and have even been investigated in treating Covid-19 . While Feverfew is generally regarded as safe, it can cause gastrointestinal issues, ulcers of the mouth, and can occasionally induce allergic reactions (“Feverfew,” 2006).
- Cytokine storm in COVID-19 and parthenolide: Preclinical evidenceby Mohsen Bahrami on May 31, 2020 at 10:00 am
A group of patients with pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were reported from China in December 2019. Although several antiviral drugs are widely tested, none of them has been approved as specific antiviral therapy for coronavirus disease 2019 (COVID-19). Accumulating evidence established a hyperinflammatory states or cytokine storm in COVID-19. Among these cytokines, IL-6 plays a key role in cytokine storm and can predict the adverse clinical…
- Aldose Reductase, Protein Glycation Inhibitory and Antioxidant of Peruvian Medicinal Plants: the Case of Tanacetum parthenium L. and Its Constituentsby Seung Hwan Hwang on May 28, 2019 at 10:00 am
Diabetes complications, including peripheral neuropathy, cataracts, impaired wound healing, vascular damage, arterial wall stiffening and retinopathy diseases, are among the most predominant health problems facing the world’s population today. The 22 Peruvian plant extracts were screened for their potential inhibitory activity against rat lens aldose reductase (RLAR) and DPPH radical scavenging. Among them, we have found that Tanacetum parthenium L. (TP) has the RLAR, AGEs and DPPH radical…
- An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headacheby Filomena Moscano on March 16, 2019 at 10:00 am
CONCLUSION: This fixed-dose Tanacetum parthenium preparation improved headache frequency and pain intensity in children affected by TTH. Despite the main limits, this study supports the use of nutraceutical in pediatric headache/migraine.
- Three newly identified lipophilic flavonoids in Tanacetum parthenium supercritical fluid extract penetrating the Blood-Brain Barrierby Krisztina Végh on November 29, 2017 at 11:00 am
Feverfew (Tanacetum parthenium L.) as a perennial herb has been known for centuries due to its medicinal properties. The main sesquiterpene lactone, parthenolide is considered to be responsible for the migraine prophylactic effect, however the pharmacological benefits of the lipophilic flavonoid components can not be neglected. Supercritical fluid extraction (7% ethanol, 22MPa, 64°C) was carried out on the leaves of Tanacetum parthenium L. from which the presence of methylated flavonoids beside…
- St. John’s Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetesby Nicoletta Galeotti on October 16, 2013 at 10:00 am
Painful diabetic peripheral neuropathy (DPN) is a common complication of diabetes and the few approved therapies for the management of pain have limited efficacy and side effects. With the aim to explore and develop new pharmacological treatments, we investigated the antihyperalgesic properties of St. John’s Wort (SJW) and feverfew in streptozotocin (STZ)-diabetic rats. Acute administration of a SJW seed extract reversed mechanical hyperalgesia with a prolonged effect. A SJW extract obtained…
Feverfew. (2006). In Drugs and Lactation Database (LactMed). Bethesda (MD): National Library of Medicine (US).
Mohsenzadeh, F., Chehregani, A., & Amiri, H. (2011). Chemical composition, antibacterial activity and cytotoxicity of essential oils of Tanacetum parthenium in different developmental stages. Pharm Biol, 49(9), 920-926. doi:10.3109/13880209.2011.556650
Parkinson, J. (1640). Theatrum botanicum: The theater of plants, or An herball of a large extent. . London: Tho. Cotes.
Rabito, M. F., Britta, E. A., Pelegrini, B. L., Scariot, D. B., Almeida, M. B., Nixdorf, S. L., . . . Ferreira, I. C. (2014). In vitro and in vivo antileishmania activity of sesquiterpene lactone-rich dichloromethane fraction obtained from Tanacetum parthenium (L.) Schultz-Bip. Exp Parasitol, 143, 18-23. doi:10.1016/j.exppara.2014.04.014
Wider, B., Pittler, M. H., & Ernst, E. (2015). Feverfew for preventing migraine. Cochrane Database Syst Rev, 4(4), Cd002286. doi:10.1002/14651858.CD002286.pub3